Most Common Diseases of Age 50+ Pulmonary vascular disease - Pulmonary embolism - Treatments In conventional medicine perspective

 Pulmonary vascular disease is defined as a condition of blood flow to the lung's artery is blocked suddenly due to a blood clot somewhere in the body, including pulmonary embolism, chronic thromboembolic disease, pulmonary arterial hypertension, pulmonary veno-occlusive disease, pulmonary arteriovenous malformations, pulmonary edema, etc.

I. Pulmonary embolism
Pulmonary embolism (PE) is defined as a condition of blockage of blood flow due to a blood clot of either in main artery of the lung or somewhere else in the body. In most cases, it is in the deep veins of the legs or pelvic. The disease is a common and affects as many as 500,000 persons annually in the United States.
VI. Treatments
A. In conventional medicine perspective
A. Medication
1. Anticoagulants, including
Heparin,Warfarin (Coumadin) and rivaroxaban (Xarelto). In the study of 256 patients with acute pulmonary embolism and pulmonary hypertension or right ventricular dysfunction but without arterial hypotension or shock. The patients were randomly assigned in double-blind fashion to receive heparin plus 100 mg of alteplase or heparin plus placebo over a period of two hours. found that when given in conjunction with heparin, alteplase can improve the clinical course of stable patients who have acute submassive pulmonary embolism and can prevent clinical deterioration requiring the escalation of treatment during the hospital stay(48).
 
2. Clot dis solvers
Patients with acute pulmonary embolism are at risk for early death or chronic morbidity. Appropriate therapy can dramatically reduce the incidence of both. Appropriate therapy can dramatically reduce the incidence of both. Oxygen and heparin therapy should be started as soon as the diagnosis is suspected. The condition of a hypotensive patient with right ventricular overload from acute pulmonary embolism usually is made worse by a fluid challenge; hypotension may be relieved by preload reduction or even by gentle diuresis. Norepinephrine (Levophed), isoproterenol hydrochloride (Isuprel), and epinephrine are the pressor agents of choice. Immediate thrombolysis is the standard of care for any patient with significant hypoxemia or hypotension due to proven pulmonary embolism. Beyond this, the potential benefit of using thrombolytic agents should be considered routinely for every patient with proven pulmonary embolism(49).

B. Surgical treatments
1. Clot removal
The aim is to remove the existed large blood clot with a thin flexible tube (catheter) through your blood vessels. According to the study by Harvard Medical School, pulmonary suction thrombectomy can be a successful interventional tool in the treatment of pulmonary thromboembolism. Removal of clot burden typically results in prompt recovery of hemodynamic stability and improved oxygenation. However, in rare cases, clot removal does not sufficiently improve the clinical situation. Herein, two patients with massive pulmonary thromboembolism are presented whose condition improved only after they received nitric oxide as an adjunct to pulmonary suction thrombectomy(50).

2. Vein filter 
The aim of placing a filter in the main vein called the inferior vena cava that leads from your legs to the right side of your heart is to filter catches and stops blood clots moving through the blood stream toward your lungs. In the study to investigate clinical experience with the Recovery filter as a retrievable inferior vena cava (IVC) filter, in one hundred seven Recovery filters were placed in 106 patients with an initial clinical indication for temporary caval filtration, found that although all the filters were placed with the intention of being removed, a large percentage of filters were not retrieved. The Recovery filter was safe and effective in preventing PE when used as a retrievable IVC filter(51).

3. Surgery  
In case of acute pulmonary embolism, emergency surgery may be the only option to remove as much as clot as possible, specially there is a large clot in your main (central) pulmonary artery, if patients are in shock and thrombolytic medication isn't working quickly enough. In the study to investigate the effectiveness of a comprehensive therapeutic algorithm including extracorporeal life support (ECLS) in high-risk acute pulmonary embolism (aPE) treated with pulmonary embolectomy, indicated that among the 25 patients, 24 had a PAOI≥0.5 and 23 had a RV-to-LV diameter ratio≥1.0. Four patients had right heart thrombi. Sixteen patients developed preoperative instability requiring inotropic and/or mechanical support. Eight in the 16 had a preoperative cardiac arrest (CA) and six of these were bridged to surgery on ECLS. Three in the 6 patients weaned ECLS after surgery and survived to discharge. The overall in-hospital mortality was 20% (n=5). A preoperative CA (Odds ratio [OR]: 16, 95% confidence interval [CI]: 1.4-185.4, p=0.027, c-index: 0.80) and a postoperative requirement of ECLS (OR: 36, 95% CI: 2.1-501.3, p=0.008, c-index: 0.85) was the pre- and postoperative predictor of in-hospital mortality. No late deaths or re-admission for recurrence were found during a median follow-up of 19 months(52). 

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Sources
(48) http://www.ncbi.nlm.nih.gov/pubmed/12374874 
(49) http://www.ncbi.nlm.nih.gov/pubmed/7816717
(50) http://www.ncbi.nlm.nih.gov/pubmed/15525752
(51) http://www.ncbi.nlm.nih.gov/pubmed/16151059 
(52) http://www.ncbi.nlm.nih.gov/pubmed/23583612 

Anti Ageing Naturally - Resveratrol and multiple molecular targets of diverse intracellular pathways

Human aging is a biological process, no one can stop, but delay it. It is possible that one person looks younger than his or her biological if one engages in healthy living life style and eating healthily by increasing the intake of good healthy food such as whole grain, fruits, vegetables, beans and legumes, etc. and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc.
Resveratrol is a type of natural phenol in the group of Stilbenoids, produced naturally by many plants, such as in grape skins and seeds, wine, nuts, peanuts, etc. when under attack by bacteria or fungi. It has been studied by many researchers for it health benefits in treating chronic diaereses, including cancer, diabetes, heart disease, etc.
Resveratrol and multiple molecular targets of diverse intracellular pathways
Resveratrol, initially used for cancer therapy, has shown beneficial effects against most degenerative and cardiovascular diseases from atherosclerosis, hypertension, ischemia/reperfusion, and heart failure to diabetes, obesity, and aging. According to the study by the University of Debrecen, during preconditioning, small doses of resveratrol can exert an adaptive stress response, forcing the expression of cardioprotective genes and proteins such as heat shock and antioxidant proteins. Similarly, resveratrol can induce autophagy, another form of stress adaptation for degrading damaged or long-lived proteins, as a first line of protection against oxidative stress. Resveratrol's interaction with multiple molecular targets of diverse intracellular pathways (e.g., action on sirtuins and FoxOs through multiple transcription factors and protein targets) intertwines with those of the autophagic pathway to give support in the modified redox environment after stem cell therapy, which leads to prolonged survival of cells(32).

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Sources  
(32) http://www.ncbi.nlm.nih.gov/pubmed/21261638

Anti Ageing Naturally - Effects of the dietary polyphenol resveratrol on human healthy aging and lifespan

Human aging is a biological process, no one can stop, but delay it. It is possible that one person looks younger than his or her biological if one engages in healthy living life style and eating healthily by increasing the intake of good healthy food such as whole grain, fruits, vegetables, beans and legumes, etc. and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc.
Resveratrol is a type of natural phenol in the group of Stilbenoids, produced naturally by many plants, such as in grape skins and seeds, wine, nuts, peanuts, etc. when under attack by bacteria or fungi. It has been studied by many researchers for it health benefits in treating chronic diaereses, including cancer, diabetes, heart disease, etc.
Effects of the dietary polyphenol resveratrol on human healthy aging and lifespan
The physiological effects of the dietary polyphenol resveratrol are being extensively studied. According to the study by the Universidad de Oviedo, resveratrol has been proposed to promote healthy aging and to increase lifespan primarily through the activation of the class III histone deacetylases (sirtuins). Although its positive effects are evident in yeast and mice they still have to be confirmed in humans. The molecular mechanisms involved in the processes are not fully understood because resveratrol may have other targets than sirtuins and the direct activation of sirtuins by resveratrol is under debate(30).
For Women Who Want to Look 5 -7 Years Younger  
The Beauty of Foods - Utilizing the Use of Foods to Look 
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Sources
(30) http://www.ncbi.nlm.nih.gov/pubmed/21613817 

Risk factors for the development of obesity in children surviving ALL and NHL

Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese. Clinically Overweight and obesity are defined indicators of a disease process characterized by the accumulation of body fat due to an excess of energy intake (nutritional intake) relative to energy expenditure (physical activity)(a). 
Lymphoma is defined as a condition of cancer in the lymphatic cells (lymphocytes) of the immune system originated in lymph nodes. It represents a group of over 20 types of cancers. Since it is a cancer in the lymph nodes, it tends to begin with several places simultaneously and spread slowly or quickly to distant parts of body, depending to the grade of the cancer.
Lymphocytes are white blood cells in the lymph nodes and bone marrow.
Risk factors for the development of obesity in children surviving ALL and NHL
In the study to investigate wether obesity [body mass index (BMI) >95th percentile] and being heavy (BMI >85th percentile) in 95 children in first remission more than 2 years after treatment for acute lymphoblastic leukemia or non-Hodgkin lymphoma at theDepartment of Pediatrics, University of California, there was no association with diagnosis, sex, age alone, radiation dose or field, metabolic diagnosis in patient/family, height z-score at diagnosis, duration of treatment, and systolic or diastolic blood pressure. Obesity and overweight were a combination of weight gain and height loss during treatment although weight continued to increase after treatment. We did not identify disease-related parameters associated with these effects(9).
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Sources
 (a) http://www.ncbi.nlm.nih.gov/pubmed/19107429   
(9) http://www.ncbi.nlm.nih.gov/pubmed/19194192

Micah's Hawaiian Tuna Poke Recipe

Guested Author:  Christine Magtoto

First, choose your tuna.
Use yellowfin tuna - ask or look for sashimi-grade tuna. This is typically found in Asian grocery stores. You can also buy them on different website stores selling meat or seafood. If the website sells sashimi-grade tuna, they'll know which cut you'll need. If you are at a store, look for tuna fillets that are bright in color, not dull, darkened or dry looking. Buy loins or thick fillets (at least one inch thick is best).
Avoid Ahi tuna that has too many white lines in the flesh. This is a soft sinew and has a slight stringy texture, not suitable for sushi. This part of the fish is fine to cook, or it can be used for roll sushi. When chopped, the sinew will easily pull away from the flesh.
Basic Ahi Tuna Poke Recipe
For beginners, this is a good base to jump off from. Add avocado, tomatoes, sliced cucumbers for a delicious and refreshing taste.
Ingredients:
4 cups ahi (yellowfin tuna, sashimi grade) diced 1/2 cup onion, minced 1/4 cup green onion, minced 1 cup soy sauce 2 tablespoons sesame oil Salt and pepper to taste
Season ahi with salt. Add all ingredients together, mix well then chill and serve with chopsticks.
Micah's Ahi Tuna Recipe
My 13-year-old is a fabulous chef. Here's her version of Tuna Poke. Delicious!
INGREDIENTS:
1 pound tuna sashimi, sliced in 1/2 inch squares 2-3 stalks of green onions, chopped 3 tablespoons of soy sauce 2 tablespoons of sesame seed oil 1 ripe avocado, cubed Sprinkle of sesame seeds salt and pepper to taste sugar to taste (optional)
Optional: Cherry tomatoes 1 cucumber, sliced
Directions:
Add all ingredients together, cover and let this marinade in the refrigerator until you're ready to serve with chopsticks!

Christine Magtoto
Founder and CEO, KidPrentice [http://www.kidprentice.com]
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Natural Juicing Recipes that All Healthy Need
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GMOs - Composition and safety analysis of Chinese traditional fermented soybean paste made by transgenic soybean

Health risk assessment of genetically modified organisms (GMOs) cultivated for food or feed is under debate throughout the world, and very little data have been published on mid- or long-term toxicological studies with mammals.
The Con's of GMOs include consumer and health groups, grain importers from European Union (EU) countries, organic farmers, environmentalists, concerned scientists, ethicist, religious rights groups, food advocacy groups, some politicians and trade protectionists
The Pro's of GMOs include private industries, research scientists, some consumers, U.S. farmers and regulatory agencies.
Here are some of their studies, please make sure you understand the intention of their differentiation.
Composition and safety analysis of Chinese traditional fermented soybean paste made by transgenic soybean
The traditional Chinese soybean paste was produced by cooked transgenic soybean fermentation with the composition of moisture 53%, amino acid 0.84% (calculated by nitrogen), votive sugar 6.21% and total acid 1.66%.  According to the study by the College of Resources and Environmental Science, China Agricultural University, the transgenic soybean paste contain abundant amino acids and vitamins (vitamin A, 42.87 IU; vitamin B, 10.31 mg; vitamin B, 20.64 mg; nicotinamide, 2.54 mg; pantothenic acid, 0.63 mg; vitamin B, 6,847 microg; folic acid, 105 microg; vitamin B, 123.85 microg; and biotin, 56.34 microg). Pathogenic microorganisms were not be detected in the transgenic fermented soybean paste(38).
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Sources
(38) http://www.ncbi.nlm.nih.gov/pubmed/18608534 

Copper and pleural mesothelioma

Copper is an essential trace element vital to the our health in maintaining the proper functions of the organs and metabolic processes.
Copper and pleural mesothelioma
Tetrathiomolybdate (TM) is an oral copper-depleting agent that has been shown to inhibit angiogenesis, and angiogenesis is a predictor of poor prognosis in malignant pleural mesothelioma. According to the study by the New York University School of Medicine, tetrathiomolybdate has antiangiogenic effects in malignant pleural mesothelioma patients after resection of gross disease, and exhibits minimal toxicity and comparable efficacy to previous multimodality trials. Tetrathiomolybdate should be evaluated for efficacy in combination with standard malignant pleural mesothelioma regimens, as well as for postsurgical maintenance therapy(52).

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Sources

(52) http://www.ncbi.nlm.nih.gov/pubmed/18640301